Molecular basis of COVID-19 pathogenesis and in silico studies of potential pharmacological treatment

COVID-19 is a disease caused by SARS-CoV-2, virus that represents serious threat to global health. The objective of the article deepen into structure structural and non-structural proteins SARS-CoV-2 their role during infection its target cells; also propose molecules from in silico studies inhibit viral cycle for potential pharmacological treatments. genome has ORFs encode sixteen (Nsp1-16), four (Spike, Envelope, Membrane, Nucleocapsid), nine accessory proteins; fulfill various functions entry cycle. In drugs such as disulfiram viomycin, found plants Azadirachta indica, tea plant, Andrographis paniculata have shown inhibitory effects on